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Recently, the discovery of human genome sequence accelerated development of biological sciences and understanding of molecular and sub-molecular basis of many, though not all functions of living organisms. This offered new chances to solving important problems of human quality of life. Working groups in the Network have been involved in molecular diagnostics as well as investigations on the aetiology of a number of human, animal and plant diseases. At present, there is an evident need for further steps to bring the results of research into practice. Scientific projects planned for realization in the frame of SB Campus KN on Molecular Diagnostics include:
- Extension of existing expertise in molecular diagnostics to highly specialized fields:
- monitoring of micrometastasis of cancer, (co-operation Gdansk-Hamburg-Oslo-Ibbenbueren)
- monitoring of microbial drug resistance using new molecular diagnostics approach developed by
- the University of Gdansk group in co-operation with the group from the University of Lund, Sweden,
- molecular epidemiology of hepatitis B based e.g. on chip technology (Gdansk-Lyon)
- population screening of some metabolic disorders (hemochromatosis, Crigler-Najjar syndrom, Gilbert’s syndrome) (Gdansk-Hamburg-Lund)
- Development of new diagnostics tools for commercial use (chip technology in co-operation with BioMerieux, denaturing gradient gel electrophoresis technology in co-operation with University of Lund).
- Development of new diagnostic strategies in the early detection of cancer metastasis (secondary cancer prevention) and therapy prediction.
- Improvement of standards in experimental research on cancer, e.g. quantitative genetic methods; preparation of samples; statistics and bioinformatics.
- Development of new diagnostics tools for large scale detection and identification of plant pathogens:
- chip technology in co-operation with COST 853
- on-site Real-Time PCR in cooperation with CSL York and CEPHID, France.
- Application of viral proteins obtained in Baculovirus system for diagnostics of animal diseases.
- Development of recombinant vaccines